Motognosis was selected for the BIH Digital Health program

We are happy to announce that the startup Motognosis, which originated from the Neurodiagnostics Labs, was selected for the BIH Digital Health program as part of the new BIH and Startupbootcamp collaboration.

Motognosis has already moved into the Startupbootcamp in Berlin Mitte and is now business coached over the next few months.

From the BIH’s press release:

Startupbootcamp, a global network of industry‐focused start‐up accelerators, runs 20 programs across five continents with a mentor and alumni network in over 30 countries. Startupbootcamp Digital Health Berlin is a leading program in Europe supporting innovative companies combining medical knowledge with smart technologies, with a special focus on behavioral change, big data and analytics, diagnostics and genomics.

“This partnership enables us to facilitate knowhow transfer between digital health start‐ups applying new technologies to advanced healthcare problems and the academic hospital Charité – Universitätsmedizin Berlin to benefit patients,” says Dr. Rolf Zettl, CFO and Member of the Executive Board of BIH. “We look forward to also explore collaboration opportunities for transformational digital health solutions with the other partners.” Partners include Philips, Sanofi in Germany, Vilua, Deutsche Apotheker‐ und Ärztebank and Munich Re.

The Startupbootcamp program provides 10 globally‐screened digital health start‐ups with hands‐on mentorship from over 100 industry experts, logistics support, office space in Berlin, and access to a global network of corporate partners and investors from across the healthcare industry. Two teams of Charité innovators are co‐located with the program as Entrepreneurs in Residence to benefit from knowhow transfer with start‐ups and mentors.

“This partnership creates common ground for BIH and SBC with the great potential to bring some truly innovative solutions to the heart of German healthcare,” says Lars Buch, Managing Director of Startupbootcamp Digital Health Berlin.

With this initiative, BIH further strengthens its commitment to supporting translational medicine in digital health, amongst other areas, to improve patients’ health and quality of life.

 

BIH Press Release

Motognosis Post on Facebook

Motognosis Website

 

Schematic Figure – Retina (Creative Commons License)

Do you need a free schematic figure of the retina for your work? We needed one, too. So we created one and publish it here under a Creative Commons License, so you can use for free in your own commercial and non-commercial works. The only thing we ask for is referencing this website, if you decide to use the figure. You are also allowed to alter it, under the condition that you keep the reference to our original version.

You can download a zipped eps vector file (ca. 3 MB) here: neurodial_retina_v1.eps

This figure is made vailable under the following Creative Commons License:
Creative Commons License
Schematic Figure – Retina by Neurodiagnostics Laboratory @ Charité – Universitätsmedizin Berlin, Germany is licensed under a Creative Commons Attribution 4.0 International License.

Schematic Figure – Macular OCT with Intraretinal Layers (Creative Commons License)

Do you need a free schematic figure of a 3D macular OCT with labelled intraretinal layers for your work? We needed one, too. So we created one and publish it here under a Creative Commons License, so you can use for free in your own commercial and non-commercial works. The only thing we ask for is referencing this website, if you decide to use the figure. You are also allowed to alter it, under the condition that you keep the reference to our original version.

You can download a zipped eps vector file (ca. 2.5 MB) here: neurodial_oct_v1.eps

This figure is made vailable under the following Creative Commons License:
Creative Commons License
Schematic Figure – Macular OCT with Intraretinal Layers by Neurodiagnostics Laboratory @ Charité – Universitätsmedizin Berlin, Germany is licensed under a Creative Commons Attribution 4.0 International License.

Schematic Figure – The Afferent Visual System (Creative Commons License)

Do you need a free schematic figure of the afferent visual system for your work? We needed one, too. So we created one and publish it here under a Creative Commons License, so you can use for free in your own commercial and non-commercial works. The only thing we ask for is referencing this website, if you decide to use the figure. You are also allowed to alter it, under the condition that you keep the reference to our original version.

You can download a zipped eps vector file (ca. 8 MB) here: neurodial_avs_v1.eps

This figure is made vailable under the following Creative Commons License:
Creative Commons License
Schematic Figure – The Afferent Visual System by Neurodiagnostics Laboratory @ Charité – Universitätsmedizin Berlin, Germany is licensed under a Creative Commons Attribution 4.0 International License.

New paper – CuBe: parametric modeling of 3D foveal shape using cubic Bézier

In this paper from our group, Sunil Yadav and colleagues have developed and validated a 3D fovea morphometry, which clearly outperforms previous approaches in the diseases of interest, mainly autoimmune neuroinflammatory disorders.

Sunil Kumar Yadav, Seyedamirhosein Motamedi, Timm Oberwahrenbrock, Frederike Cosima Oertel, Konrad Polthier, Friedemann Paul, Ella Maria Kadas, and Alexander U. Brandt

Abstract

Optical coherence tomography (OCT) allows three-dimensional (3D) imaging of the retina, and is commonly used for assessing pathological changes of fovea and macula in many diseases. Many neuroinflammatory conditions are known to cause modifications to the fovea shape. In this paper, we propose a method for parametric modeling of the foveal shape. Our method exploits invariant features of the macula from OCT data and applies a cubic Bézier polynomial along with a least square optimization to produce a best fit parametric model of the fovea. Additionally, we provide several parameters of the foveal shape based on the proposed 3D parametric modeling. Our quantitative and visual results show that the proposed model is not only able to reconstruct important features from the foveal shape, but also produces less error compared to the state-of-the-art methods. Finally, we apply the model in a comparison of healthy control eyes and eyes from patients with neuroinflammatory central nervous system disorders and optic neuritis, and show that several derived model parameters show significant differences between the two groups.

 

Read more at Biomedical Optics Express, Vol. 8, Issue 9, pp. 4181-4199 (2017).

Neuroimmunological Colloquium, Michael Demetriou

Dear Colleagues,

 

The  next Neuroimmunological colloquium will take place on Monday, 29th May, 2017. In this  session we are privileged to have Prof. Michael Demetriou, MD-PhD , of the Institute for Immunology, University of California, Irvine, USA.

 

Topic:  The glycobiology of T cell dysfunction in  autoimmune diseases.

 

Venue: Campus Charité Mitte, Hufelandweg 6, Ferdinand Sauerbruch Hörsaal 4.

Time:  14:00  

We will have scientific discussions with him further after his talk and you are all invited to join in the discussions.

We provide continuing education credits by the Deutsche Ärztekammer and graduate student credits for Medical Neuroscience students.

Lunch and light drinks will be provided.

This year 2017 and for the rest of the Semester we have an exciting schedule of national and international presenters with expertise in diverse sub-areas of neuroimmunology.

Our hope is that this seminar will provide a platform to exchange ideas, create new collaborations, re-connect with colleagues and learn about the novel research at the forefront of our neuroimmunology community.

 

Please feel free to forward the invitation to your colleagues and friends.

 

Looking forward to seeing you there!

 

Best regards,

Priscilla Koduah

 

……………………………………………

Priscilla Koduah, PhD Candidate Neurodiagnostics Laboratory and Clinical Neuroimmunology Group NeuroCure Clinical Research Center Charité – Universitätsmedizin Berlin Charitéplatz 1 10117 Berlin, Germany Email: priscilla.koduah@charite.de

Single-subject independent component analysis-based intensity normalization in non-quantitative multi-modal structural MRI Authors

New publication in Hum Brain Mapp. 2017 Apr 22. doi: 10.1002/hbm.23615.

Papazoglou S, Würfel J, Paul F, Brandt AU, Scheel M.

Non-quantitative MRI is prone to intersubject intensity variation rendering signal intensity level based analyses limited. Here, we propose a method that fuses non-quantitative routine T1-weighted (T1w), T2w, and T2w fluid-saturated inversion recovery sequences using independent component analysis and validate it on age and sex matched healthy controls. The proposed method leads to consistent and independent components with a significantly reduced coefficient-of-variation across subjects, suggesting potential to serve as automatic intensity normalization and thus to enhance the power of intensity based statistical analyses. To exemplify this, we show that voxelwise statistical testing on single-subject independent components reveals in particular a widespread sex difference in white matter, which was previously shown using, for example, diffusion tensor imaging but unobservable in the native MRI contrasts. In conclusion, our study shows that single-subject independent component analysis can be applied to routine sequences, thereby enhancing comparability in-between subjects. Unlike quantitative MRI, which requires specific sequences during acquisition, our method is applicable to existing MRI data.

Read more on the publisher’s website.

Contribution of blood vessels to retinal nerve fiber layer thickness in NMOSD

New publication in Neurol Neuroimmunol Neuroinflamm. 2017 Apr 18;4(3):e338. doi: 10.1212/NXI.0000000000000338. eCollection 2017 May.

Oertel FC, Zimmermann H, Mikolajczak J, Weinhold M, Kadas EM, Oberwahrenbrock T, Pache F, Bellmann-Strobl J, Ruprecht K, Paul F, Brandt AU.

Neuromyelitis optica spectrum disorders (NMOSDs) are relapsing inflammatory demyelinating disorders with optic neuritis (ON) as the hallmark. ON causes neuroaxonal damage to the optic nerve and retina, regularly leading to severely impaired visual acuity (VA).

Peripapillary retinal nerve fiber layer (pRNFL) thickness measured by optical coherence tomography (OCT) has been increasingly recognized as a marker for neuroaxonal damage and correlate of visual dysfunction. As such, pRNFL is implemented as an outcome in clinical trials of ON-associated disorders. Blood vessels (BVs) running within the pRNFL contribute approximately 13% to an average RNFL thickness2 and could present an important confounder when tracking small pRNFL changes or in diseases with severe thinning such as NMOSD. Against this background, the objective of this study was to investigate the influence of retinal BVs on pRNFL measurements in an NMOSD cohort.

Read more on PubMed Central.

Microstructural visual system changes in AQP4-antibody-seropositive NMOSD

New publication in Neurol Neuroimmunol Neuroinflamm. 2017 Feb 22;4(3):e334. doi: 10.1212/NXI.0000000000000334. eCollection 2017 May.

Oertel FC, Kuchling J, Zimmermann H, Chien C, Schmidt F, Knier B, Bellmann-Strobl J, Korn T, Scheel M, Klistorner A, Ruprecht K, Paul F, Brandt AU.

OBJECTIVE: To trace microstructural changes in patients with aquaporin-4 antibody (AQP4-ab)-seropositive neuromyelitis optica spectrum disorders (NMOSDs) by investigating the afferent visual system in patients without clinically overt visual symptoms or visual pathway lesions.

METHODS: Of 51 screened patients with NMOSD from a longitudinal observational cohort study, we compared 6 AQP4-ab-seropositive NMOSD patients with longitudinally extensive transverse myelitis (LETM) but no history of optic neuritis (ON) or other bout (NMOSD-LETM) to 19 AQP4-ab-seropositive NMOSD patients with previous ON (NMOSD-ON) and 26 healthy controls (HCs). Foveal thickness (FT), peripapillary retinal nerve fiber layer (pRNFL) thickness, and ganglion cell and inner plexiform layer (GCIPL) thickness were measured with optical coherence tomography (OCT). Microstructural changes in the optic radiation (OR) were investigated using diffusion tensor imaging (DTI). Visual function was determined by high-contrast visual acuity (VA). OCT results were confirmed in a second independent cohort.

RESULTS: FT was reduced in both patients with NMOSD-LETM (p = 3.52e-14) and NMOSD-ON (p = 1.24e-16) in comparison with HC. Probabilistic tractography showed fractional anisotropy reduction in the OR in patients with NMOSD-LETM (p = 0.046) and NMOSD-ON (p = 1.50e-5) compared with HC. Only patients with NMOSD-ON but not NMOSD-LETM showed neuroaxonal damage in the form of pRNFL and GCIPL thinning. VA was normal in patients with NMOSD-LETM and was not associated with OCT or DTI parameters.

CONCLUSIONS: Patients with AQP4-ab-seropositive NMOSD without a history of ON have microstructural changes in the afferent visual system. The localization of retinal changes around the Müller-cell rich fovea supports a retinal astrocytopathy.

Read more on PubMed Central.

Winter Semester 2017, NIC 2

Winter Semester 2017-NIC 2

 

 

 

 

 

 

January 23rd

 NEUROIMMUNOLOGICAL COLLOQUIUM @ AG Paul

Winter Semester 2017

Mondays at 14:00h

Charité Mitte Campus – Universitätsmedizin Berlin

Ferdinand Sauerbruch Hörsaal 4, Hufelandweg 6

 

 Volker Siffrin, MD

Max-Delbrück-Centrum for Molecular Medicine, Berlin

Introduction to Basic Science – Neuroimmunology

 

January  30th Michael Hoffmann, MD

University Eye Clinic, Otto von Guericke University, Madgeburg Germany

Electrophysiology of Visual Dysfunction

February  6th Marcus D’Souza, MD

Department of Neurology, University of Basel, Switzerland

Capturing disability in MS with kinect

February 13th Mir-Farzin Mashreghi, PhD

German Rheumatism Research Center, DRFZ, Berlin

The role of Regulatory RNA in Proinflammatory T-helper cells

February  20th

 

Véronique Blanchard, PhD

Institut für Labormedizin, Klinische Chemie und Pathobiochemie, Charité

The Glycome in Health and Disease